Towards real time monitoring of blood dialysis in chronic kidney disease

At IMEC (Thesis)

Project Description

Chronic kidney disease (CKD) affects about 10 percent of the population worldwide. While kidney transplantation remains the best treatment option, the lack of suitable organs makes that the majority of end stage renal disease (ESRD) patients is dependent upon lifestyle-limiting dialysis treatment.


For this, patients must visit the hospital at multiple times per week (normally 3 times/week) and during the treatment a machine is connected to the blood system of the patient to remove waste, extra chemicals and fluid from the blood. The machine thus helps the body to keep electrolytes and fluid in balance in case the kidney is no longer able to perform these important functions. Information on electrolytes concentrations is currently only available before and/or after the dialysis treatment using regular blood sampling. At imec a revolutionary miniaturized sensor technology has been developed with built-in reference to enable continuous sensing without the need for recalibration. Using this sensor technology it becomes possible to obtain information of electrolyte concentrations during dialysis, thereby enabling an optimized, individualized dialysis treatment.


In this project, the student will apply the imec in-line ion-selective sensor platform in a clinical setting to compare measurements of Na+, K+, Ca2+, Cl- and pH with clinical chemistry lab gold standard methods. To this end the student will perform experiments to calibrate the in-line platform and will implement the measurement in a clinical research setting. The student will collect data during dialysis treatment and will compare the outcome from these measurements with gold standard clinical chemistry lab values. The student will write a report on the findings.


Your Tasks

  • Learn to know the in-line platform.
  • Calibrate the platform using lab-prepared mixtures with known concentrations of ions.
  • Implement the in-line sensor into a clinical setup.
  • Collect data from spent dialysate.
  • Compare outcomes with those of gold standard methods and write a report.


Your Profile

  • You are an Msc student in (Bio)medical Engineering/Technical Medicine.
  • You are available for a period of 9 months or more.
  • Affinity with technique in a clinical (research) setting.
  • Excellent communication and people skills (required in a clinical setting).
  • Entitled to do an internship in the Netherlands.
  • Motivated student eager to work independently and expand knowledge in the field.
  • Good written and verbal English skills.
  • Dutch verbal skills form a plus (not all patients and nurses speak English fluently).

Location: Eindhoven, Connected Health Solutions R&D




Click on 'apply' to submit your application. You will then be redirected to e-recruiting.


Please be advised that non-EU/EEA country students that are studying outside of the Netherlands, need to have a work-permit to be able to do an internship in the Netherlands.


Appy now