Today's world is full of intelligent electronic devices based on conventional, rigid silicon chips. Making intelligent systems flexible opens up the possibility of embedding that functionality directly into clothing, plastics and construction materials, changing the way we interact with electronics. Building smart systems would also make it possible to produce electronics in high-throughput roll-to-roll processes, cutting manufacturing costs. Holst Centre and its ecosystem are the forefront of a wide range of fundamental technologies that will make smart flexible systems possible.