What next for healthcare monitoring?

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The world is aging. There were 600 million people aged over 60 in 2000, and predictions suggest there will be more than 2 billion by 2050. As we get older, we typically get more health problems. Long-term illnesses like Parkinson's and Alzheimer's are rising and are set to accelerate. These conditions can be treated, but at a cost. Already, many countries spend as much as 20% of the GDP on healthcare.


So how can we give more people a higher quality of life for longer while keeping healthcare costs under control. The answer lies in keeping them out of hospital as much as possible. By giving people access to high-quality, responsive care in their own homes, they can live as normal a life as possible.


Where with wearables?

This ambition is driving a trend towards wearable monitoring devices, a trend that Holst Centre has led for many years. Through developments such as our Health patch, we have shown it is possible to track primary vital signs – including body temperature, heart rate, breathing rate, blood pressure and blood oxygen levels – with clinical quality in real-life setting using comfortable, unobtrusive wearables. 


Now, with the technical feasibility well established, we are working with clinical and industrial partners to explore the business and use cases that will allow wearable devices to become a frontline tool in keeping people healthy. We know it is possible to track all five vital signs simultaneously, but is that the most cost-effective way to help people and their care providers? And if we concentrate on just a few vital signs, which ones? At the same time, does the market need / want a single wearable healthcare monitoring platform? Or should we focus on tailored solutions for specific diseases?

These are all still open questions. And we would love to hear from any interested parties on how wearables could bring most benefit to healthcare monitoring.


Continuous prevention

Holst Centre has always wanted to help shift the focus of healthcare from managing disease to managing health. And when it comes to health, I think everyone agrees that prevention is better than cure.


One way we could prevent disease is to allow people to routinely monitor so-called bio-markers in their bodies. These are molecules that can give early warning of potential issues before you feel any symptoms. For example, blood glucose levels can highlight the risk of diabetes, cortisol indicates stress and bilirubin suggests a danger of jaundice in newborn babies.


Combining bio-marker early warnings with personalized information and advice could help people or their doctors take action earlier. And the earlier you act, generally the smaller the change required and the better the result.


However, there are thousands of molecules that are potentially interesting biomarkers for managing our health. Which diseases and which biomarkers should the industry focus on? And how do we monitor them in a non-invasive way? We can't expect billions of people to undergo blood tests every day.


Picking the right path together

To answer the second question first, Holst Centre is already exploring what is feasible. In particular, we are looking at what you can measure using sweat, breath or a combination of both. Sub-dermal monitoring through micro-needles so small that you don't even feel them is another possibility. As is using microfluidics to analyze blood. Using trans-dermal light – as in pulse oximeter – has also been suggested in some places. But my feeling is that the concentrations of bio-markers would be too low for this to be effective.


The first question – which molecules are most interesting – is not one any single organization can answer on its own. So we are talking with our colleagues at TNO and imec, and also with clinical partners and hospitals to identify target diseases and their biomarkers. There is a lot of interest on all sides to find the right answers to that question.


Alongside what is technologically and medically possible, there are also big questions about whether industry and the market are ready for continuous bio-marker monitoring. Are companies looking for this kind of solution now or in a few years' time? Are insurers and healthcare providers willing to pay for them given the potential savings down the line?


We are already in discussions with various players across the healthcare chain to define common roadmaps and timelines. But we are eager to broaden these discussions and hear the opinions and needs of more people and organizations.


So if you have a view on healthcare monitoring for today or tomorrow, please get in touch via the comments section below or contact us at contact@holstcentre.com.


Ton van Mol

Ton van Mol

Ton van Mol is Managing Director of Holst Centre / TNO.



  • Guy Bisschops from Neuroteg AI
    16 July 2017 - 14:46

    Healthcare monitoring is the future of healthcare and wearables are the sensors to make personalzed medicines possible.. For brain diseases like Alzheimer's disease ( AD ) to make a diagnosis based on biomarkers in blood, urine or spinal fluid ...it make no sense...expensive, invasive and we can't do monitoring of the effectiveness of a treatment or therapy...The result is that after 40 years of Alzheimer research and more than 100.000 clinical studies we have no cure.. Also neuroimaging for AD diagnosis (PET scans, MRI, CN) are based on the controversial hypothesis of beta-amyloid. The big problem is misdiagnosis and 50% of these patients shall die without a diagnosis. Everyone can understand that a doctor can't make a diagnose based only on blood pressure or temperature or cholesterol...it shall be always a combination of different symptoms...
    With eye tracking we can measure "microsaccades" the early first symptoms of AD...or tremor, drift...10-15 years before neurological symptoms appears. Can we make a diagnose based on eye tracking...no but it is an important parameter to make a better diagnosis...with EEG sensorchip we can see "silent seizures" an important indicator of AD, with TCD sensorchip we can measure blood flow in the venes and have an indication of SVD...
    We combine all these digital parameters with neurocognitieve tests...big data for personalized medicines...for better treatment and monitoring...
    Neuroteg AI (www.neuroteg.com )
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      25 August 2017 - 10:46

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